Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells.
Evgenii V PlotnikovInnokentiy S LosenkovElena V EpimakhovaNikolay A BokhanPublished in: Advanced pharmaceutical bulletin (2019)
Purpose: Aim of present work was to study cytoprotective properties of lithium pyruvate, as a prospective pharmacological agent. Pyruvate has a lot of potential benefits due to positive influence on cell metabolism. Lithium is "gold-standard" mood-stabilizer. Combination of both may lead advantages. Methods: Lithium pyruvate was tested as cytoprotector on human blood mononuclears under induced oxidative stress. Cells were obtained from healthy donors and patients with alcoholism. The detection of cell viability, apoptosis and determination of oxidative stress level were conducted by flow cytometry. Results: Lithium pyruvate showed excellent cytoprotective properties in normal and oxidation conditions. This effect was independent from cell donor health status. It was shown on cells from healthy donors and alcoholics patients. Conclusion: Obtained results allow considering lithium pyruvate as potential normothymic agents (mood stabilizer) with excellent cytoprotective properties.
Keyphrases
- oxidative stress
- induced apoptosis
- solid state
- cell cycle arrest
- endothelial cells
- flow cytometry
- endoplasmic reticulum stress
- end stage renal disease
- single cell
- bipolar disorder
- ejection fraction
- cell therapy
- chronic kidney disease
- pluripotent stem cells
- newly diagnosed
- signaling pathway
- induced pluripotent stem cells
- stem cells
- peritoneal dialysis
- physical activity
- depressive symptoms
- bone marrow
- pi k akt
- climate change
- mesenchymal stem cells
- kidney transplantation
- diabetic rats
- ischemia reperfusion injury
- heat stress