Downregulation of HOXA13 sensitizes human esophageal squamous cell carcinoma to chemotherapy.
Qi ShiLuyan ShenBin DongHao FuXiaozheng KangLiang DaiYongbo YangWanpu YanKe-Neng ChenPublished in: Thoracic cancer (2018)
High HOXA13 expression was associated with inferior tumor regression grade and poor overall survival in ESCC patients treated with neoadjuvant chemotherapy. HOXA13 increased cisplatin-resistance and promoted EMT in ESCC cells.
Keyphrases
- neoadjuvant chemotherapy
- locally advanced
- induced apoptosis
- long non coding rna
- poor prognosis
- long noncoding rna
- signaling pathway
- rectal cancer
- sentinel lymph node
- lymph node
- endothelial cells
- endoplasmic reticulum stress
- cell cycle arrest
- squamous cell carcinoma
- epithelial mesenchymal transition
- radiation therapy
- oxidative stress
- cell proliferation
- binding protein
- cell death
- early stage
- chemotherapy induced