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Randomized Phase II Trial of Sipuleucel-T with or without Radium-223 in Men with Bone-metastatic Castration-resistant Prostate Cancer.

Catherine Handy MarshallWei FuHao WangJong Chul ParkTheodore L DeWeesePhuoc T TranDaniel Y SongSerina KingMichaella AffulJulia HurrelbrinkCharlotte ManoguePatrick CotognoNancy P MoldawerPedro C BarataCharles G DrakeEdwin M PosadasAndrew J ArmstrongA Oliver SartorEmmanuel S Antonarakis
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our data raise the possibility of greater clinical activity with the combination of sipuleucel-T and radium-223 in men with asymptomatic bone mCRPC, despite the paradoxically lower immune responses observed. Additional study to confirm these findings in a larger trial is warranted.
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