Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4.
Yulang JiangDengcheng HuiZiyang PanYongxin YuLu LiuXiaofan YuChao WuMingyu Sun
Published in: Journal of cancer research and clinical oncology (2024)
This study showed that curcumin significantly decreased the proliferation of HCC cells and significantly increased the sensitivity of ferroptosis. These results suggest that ACSL4 is a viable target for curcumin-induced ferroptosis in treating HCC.