Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy.

Yun HuAlexey RevenkoHampartsoum BarsoumianGenevieve BertoletNatalie Wall FowlkesHadi MaaziMorgan Maureen GreenKewen HeDuygu SezenTiffany A VossClaudia S Kettlun LeytonFatemeh MasrorpourZahid RafiqNahum Puebla-OsorioCarola LeuschnerRobert MacLeodMaria Angelica CortezJames W Welsh

Published in: Journal of experimental & clinical cancer research : CR (2024)

The MerTK ASO can significantly downregulate the expression of MerTK on TAMs, thereby promoting antitumor immune response. The combination of MerTK ASO with immunoradiotherapy can safely and significantly slow tumor growth and improve survival.

Keyphrases

tyrosine kinase
immune response
epidermal growth factor receptor
poor prognosis
dendritic cells
binding protein
combination therapy
nucleic acid
replacement therapy
smoking cessation