Controversies in antenatal corticosteroid treatment.
Iniyaval ThevathasanJoanne M SaidPublished in: Prenatal diagnosis (2020)
Antenatal corticosteroids are now established as one of the cornerstones of therapy in the prevention of neonatal morbidity and mortality prior to preterm birth. Although this practice is widely accepted, a significant number of controversies exist. This review explores the knowledge gaps regarding the use of antenatal corticosteroids in the preterm, late preterm and term populations. Furthermore, the role of antenatal corticosteroids in special populations, such as diabetes, multiple pregnancies and periviable gestations, where high-quality data from randomized controlled trials are lacking, is also considered.
Keyphrases
- preterm birth
- gestational age
- low birth weight
- healthcare
- randomized controlled trial
- type diabetes
- cardiovascular disease
- pregnant women
- primary care
- preterm infants
- electronic health record
- systematic review
- stem cells
- machine learning
- clinical trial
- bone marrow
- big data
- glycemic control
- deep learning
- insulin resistance
- replacement therapy
- study protocol
- double blind
- data analysis