Dose-escalated radiotherapy for unresectable or locally recurrent pancreatic cancer: Dose volume analysis, toxicity and outcome of 28 consecutive patients.
Sebastian ZschaeckBibiana BlümkePeter WustDavid KaulMarcus BahraHanno RiessFritz KleinMarianne SinnUwe PelzerVolker BudachPirus GhadjarPublished in: PloS one (2017)
Dose escalated normo-fractionated radiotherapy for LAPC/LRPC seems feasible and suitable to prolong local control and in consequence long-term survival. However, in-field local progression is still frequently observed and possibilities to increase the local effectiveness should be evaluated. Exposure of the spleen was predictive for acute toxicity and should be further investigated.
Keyphrases
- locally advanced
- early stage
- end stage renal disease
- ejection fraction
- radiation therapy
- newly diagnosed
- oxidative stress
- randomized controlled trial
- systematic review
- liver failure
- chronic kidney disease
- radiation induced
- squamous cell carcinoma
- rectal cancer
- patient reported outcomes
- small cell lung cancer
- drug induced
- mass spectrometry
- high resolution
- hepatitis b virus
- oxide nanoparticles
- brain metastases