SARS-CoV-2 Covid-19 Infection During Pregnancy and Differential DNA Methylation in Human Cord Blood Cells From Term Neonates.
Pedro UrdaySuhita Gayen Nee' BetalRochelle Sequeira GomesHuda B Al-KouatlyKolawole SolarinJoanna Sy ChanDongmei LiIrfan RahmanSankar AddyaRupsa C BoeligZubair H AghaiPublished in: Epigenetics insights (2023)
COVID-19 induces differential DNA methylation in umbilical cord blood cells. The differentially methylated genes may contribute to hepatic, renal, cardiac, developmental and immunological disorders in offspring born to mothers with COVID-19 infection during pregnancy, and their developmental regulation.
Keyphrases
- dna methylation
- sars cov
- cord blood
- umbilical cord
- genome wide
- mesenchymal stem cells
- induced apoptosis
- low birth weight
- gene expression
- respiratory syndrome coronavirus
- gestational age
- endothelial cells
- preterm infants
- coronavirus disease
- cell cycle arrest
- induced pluripotent stem cells
- left ventricular
- copy number
- pluripotent stem cells
- endoplasmic reticulum stress
- heart failure
- bone marrow
- signaling pathway
- oxidative stress
- cell proliferation
- skeletal muscle
- bioinformatics analysis
- insulin resistance