MRI radiomics features of mesorectal fat can predict response to neoadjuvant chemoradiation therapy and tumor recurrence in patients with locally advanced rectal cancer.
Vetri Sudar JayaprakasamViktoriya ParoderPeter GibbsRaazi BajwaNatalie GangaiRamon E SosaIva PetkovskaJennifer S Golia PernickaJames Louis FuquaDavid D B BatesMartin R WeiserAndrea CercekMarc J GollubPublished in: European radiology (2021)
• Mesorectal fat contains important prognostic information in patients with locally advanced rectal cancer (LARC). • Radiomics features of mesorectal fat were significantly different between those who achieved complete vs incomplete pathologic response (accuracy 83.9%, 95% CI: 78.6-88.4%). • Radiomics features of mesorectal fat were significantly different between those who did vs did not develop local or distant recurrence (accuracy 78.3%, 95% CI: 72.0-83.7% and 87.0%, 95% CI: 81.6-91.2% respectively).
Keyphrases
- rectal cancer
- locally advanced
- neoadjuvant chemotherapy
- adipose tissue
- phase ii study
- contrast enhanced
- fatty acid
- lymph node metastasis
- magnetic resonance imaging
- free survival
- stem cells
- clinical trial
- computed tomography
- magnetic resonance
- open label
- social media
- diffusion weighted imaging
- smoking cessation
- cell therapy