Hydrophobic immiscibility controls self-sorting or co-assembly of peptide amphiphiles.
Rie WakabayashiRino ImataniMutsuhiro KatsuyaYuji HiguchiHiroshi NoguchiNoriho KamiyaMasahiro GotoPublished in: Chemical communications (Cambridge, England) (2022)
Pairs of peptide amphiphiles with immiscible hydrophobic tails were synthesized and their assembly formation was investigated. These pairs formed self-sorting supramolecular fibres using a standard heating-cooling protocol, while one pair with longer hydrophobic tails formed a co-assembly when an additional heating process was applied.