Overexpressing CCT6A Contributes To Cancer Cell Growth By Affecting The G1-To-S Phase Transition And Predicts A Negative Prognosis In Hepatocellular Carcinoma.

Guofen ZengJialiang WangYanlin HuangYi-Fan LianDongmei ChenHuan WeiChaoshuang LinYuehua Huang

Published in: OncoTargets and therapy (2019)

CCT6A may contribute to HCC cell proliferation by accelerating the G1-to-S transition, as it maintains the expression of cyclin D. CCT6A could be considered an oncogene of HCC and could be used as a prognostic biomarker for HCC.

Keyphrases

cell proliferation
cell cycle
poor prognosis
papillary thyroid
squamous cell
squamous cell carcinoma
binding protein
pi k akt
signaling pathway
childhood cancer