Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study.
Jose Angel Pineda-PardoCarmen Gasca-SalasBeatriz Fernández-RodríguezRafael Rodriguez-RojasMarta Del ÁlamoIgnacio ObesoFrida Hernández-FernándezClara TrompetaRaúl Martínez FernándezMichele MatarazzoDavid Mata-MarínPasqualina GuidaAlicia DuqueDavid AlbilloIsabel Plaza de Las HerasJuan I MonteroGuglielmo FoffaniGabriella ToltsisItay RachmilevitchJavier BlesaJose A ObesoPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
These initial results indicate that FUS-mediated striatal BBB opening is feasible and safe and therefore could become an effective tool to facilitate the delivery of putative neurorestorative molecules in PD. © 2022 International Parkinson and Movement Disorder Society.