Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies.
Erik H P van PuttenAnne KleijnVictor W van BeusechemDavid NoskeCor H J LamersAnna L de GoedeSander IdemaDaphna HoefnagelJenneke J KloezemanJuan FueyoFrederick F LangCharlotte E TeunissenRené M VernhoutCathy BakkerWinald R GerritsenDavid T CurielArnold G VultoMartine L M LamfersClemens M F DirvenPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
CED of Delta24-RGD not only in the tumor but also in surrounding brain is safe, induces a local inflammatory reaction, and shows promising clinical responses.