Transforming growth factor-β1 inhibits interleukin-1β-induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells.
Nedra DhaouadiAli NehmeWissam H FaourPatrick FeugierCatherine CeruttiKamel KacemAli H EidJacques-Yuan LiKazem ZibaraPublished in: Fundamental & clinical pharmacology (2021)
TGF-β1 abrogated IL-1β-induced expression of inflammatory genes and elastolytic activity in cultured human vSMCs. Thus, TGF-β1 can play a crucial role in impairing IL-1β-induced vascular inflammation and damage involved in the etiology of cardiovascular diseases.
Keyphrases
- transforming growth factor
- endothelial cells
- high glucose
- oxidative stress
- vascular smooth muscle cells
- diabetic rats
- epithelial mesenchymal transition
- poor prognosis
- genome wide
- drug induced
- angiotensin ii
- type diabetes
- dna methylation
- signaling pathway
- metabolic syndrome
- genome wide identification
- transcription factor