BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes.
Shuiyan WuYou JiangYi HongXinran ChuZimu ZhangYanfang TaoZiwei FanZhenjiang BaiXiaolu LiYanling ChenZhiheng LiXin DingHaitao LvXiaoli DuSu Lin LimYongping ZhangSaihu HuangJun LuJian PanShaoyan HuPublished in: Cancer cell international (2021)
BRD4 indicates a poor prognosis in T-ALL. The BRD4 degrader ARV-825 can effectively suppress the proliferation and promote apoptosis of T-ALL cells via BET protein depletion and c-Myc inhibition, thus providing a new strategy for the treatment of T-ALL.
Keyphrases
- poor prognosis
- cell cycle arrest
- acute lymphoblastic leukemia
- long non coding rna
- induced apoptosis
- cell death
- endoplasmic reticulum stress
- pi k akt
- signaling pathway
- oxidative stress
- genome wide
- allogeneic hematopoietic stem cell transplantation
- binding protein
- gene expression
- bioinformatics analysis
- cell proliferation
- acute myeloid leukemia
- small molecule