Short chain fatty acids for the risk of diabetic nephropathy in type 2 diabetes patients.

Yang LiGuo-Qiang QinWan-Ying WangXu LiuXiao-Qian GaoJun-Hui LiuTao ZhengWei ZhangLan ChengKun YangXin YouYue WuZhong-Ze Fang

Published in: Acta diabetologica (2022)

Acetate, butyrate and isovalerate were negatively associated with DN. Isobutyrate was positively associated with DN. Serum high propionate and high isobutyrate worked independently and synergistically to increase the risk of DN in T2D. Presence of hypertension further amplified the effect of copresence of high propionate on DN risk.

Keyphrases

diabetic nephropathy
type diabetes
fatty acid
end stage renal disease
ejection fraction
blood pressure
newly diagnosed
metabolic syndrome