Regulatory mechanisms of heme regulatory protein BACH1: a potential therapeutic target for cancer.
Abirami ArunachalamDinesh Kumar LakshmananGuna RavichandranSoumi PaulSivakumar ManickamPalanirajan Vijayaraj KumarSivasudha ThilagarPublished in: Medical oncology (Northwood, London, England) (2021)
A limited number of overexpressed transcription factors are associated with cancer progression in many types of cancer. BTB and CNC homology 1 (BACH1) is the first mammalian heme-binding transcription factor that belongs to the basic region leucine zipper (bZIP) family and a member of CNC (cap 'n' collar). It forms heterodimers with the small musculoaponeurotic fibrosarcoma (MAF) proteins and stimulates or suppresses the expression of target genes under a very low intracellular heme concentration. It possesses a significant regulatory role in heme homeostasis, oxidative stress, cell cycle, apoptosis, angiogenesis, and cancer metastasis progression. This review discusses the current knowledge about how BACH1 regulates cancer metastasis in various types of cancer and other carcinogenic associated factors such as oxidative stress, cell cycle regulation, apoptosis, and angiogenesis. Overall, from the reported studies and outcomes, it could be realized that BACH1 is a potential pharmacological target for discovering new therapeutic anticancer drugs.
Keyphrases
- transcription factor
- papillary thyroid
- cell cycle
- oxidative stress
- squamous cell
- healthcare
- squamous cell carcinoma
- cell proliferation
- endothelial cells
- poor prognosis
- gene expression
- lymph node metastasis
- insulin resistance
- dna damage
- ischemia reperfusion injury
- childhood cancer
- long non coding rna
- binding protein
- risk assessment
- small molecule
- dna binding
- wound healing
- drug induced
- heat stress
- bioinformatics analysis
- amino acid
- heat shock