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Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain.

Zekang XiongJun DingJinge ZhouSheng YaoJin ZhengXiao-Dong Guo
Published in: BMC musculoskeletal disorders (2020)
The expression of HIF-1α/Notch increased in the NP cells of patients with MC I and MC II. HIF-1α and Notch-related components are potential biomarkers and the HIF-1α/Notch signaling pathway may serve as a promising therapeutic target for disc degeneration in patients with MCs.
Keyphrases
  • induced apoptosis
  • signaling pathway
  • cell cycle arrest
  • cell proliferation
  • pi k akt
  • endothelial cells
  • endoplasmic reticulum stress
  • poor prognosis
  • epithelial mesenchymal transition
  • oxidative stress
  • binding protein