Optimal methods for analyzing targeted pairwise knockout screens.

Juihsuan ChouNazanin Esmaeili AnvarReem ElghaishJunjie Chen Traver Hart

Published in: bioRxiv : the preprint server for biology (2024)

The ZdLFC method offers a robust framework for scoring synthetic lethal interactions from paralog screens, providing consistent results across different cell lines without requiring a training set of known positive interactors.

Keyphrases

high throughput
genome wide
cancer therapy
dna methylation
virtual reality
gene expression
drug delivery