Attenuated Expression of SLCO2A1 Caused by DNA Methylation in Pediatric Inflammatory Bowel Disease.

Natsuki ItoTakahiro KudoHidetaka EguchiKeisuke JimboAtsushi FuruhataToshiaki OkunoIchiro TakeuchiKatsuhiro AraiTakashi IshigeYasushi OkazakiToshiaki Shimizu

Published in: Inflammatory bowel diseases (2023)

Local DNA methylation attenuated SLCO2A1 expression, which may evoke local inflammation of the mucosa by the unincorporated PG. These findings may improve our understanding of the epigenetic mechanisms underlying IBD development.

Keyphrases

dna methylation
poor prognosis
gene expression
genome wide
oxidative stress
binding protein
long non coding rna
copy number