Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells.

Irma Beatriz Mitre-Aguilar Tonatiuh Barrios-Garcia Victor M Ruiz-Lopez Alberto J Cabrera-Quintero Nancy Raquel Mejía-Domínguez José Luis Ventura-Gallegos Daniel Moreno-Mitre Alejandro Aranda-Gutierrez Minerva Janini Mejía-Rangel Alma R Escalona-Guzman Yanin Chavarri Guerra Alfonso Leon-Del-Rio Alejandro Zentella-Dehesa

Published in: BMC cancer (2019)

The effect of GCs against TNF-mediated cytotoxicity involves increased mRNA expression and sustained protein levels of c-IAP1 and XIAP. The antagonist effects of RU486 and the qRT-PCR results also suggest the role of the GR in this process. This finding may have clinical implications because the GR and IAPs are expressed in breast tumor samples.

Keyphrases

rheumatoid arthritis
induced apoptosis
poor prognosis

binding protein
cell cycle arrest

endoplasmic reticulum stress
protein protein

cell proliferation
energy transfer