What's behind 68Ga-PSMA-11 uptake in primary prostate cancer PET? Investigation of histopathological parameters and immunohistochemical PSMA expression patterns.
Jan H RüschoffDaniela A FerraroUrs J MuehlematterRiccardo LaudicellaThomas HermannsAnn-Katrin RodewaldHolger MochDaniel EberliIrene A BurgerNiels J RuppPublished in: European journal of nuclear medicine and molecular imaging (2021)
We describe PSMA%neg, infiltrative growth pattern, smaller tumour size and WHO/ISUP grade group 2 as parameters associated with a lower 68Ga-PSMA-11 uptake in prostate cancer. These findings can serve as fundament for future biopsy-based biomarker development to enable an individualized, tumour-adapted imaging approach.