Inflammatory stays inflammatory: a subgroup of systemic sclerosis characterized by high morbidity and inflammatory resistance to cyclophosphamide.
Aleksey MitevLisa ChristDaria FeldmannMoritz BinderKim MöllerAnna-Maria KanneThomas HüglePeter M VilligerReinhard E VollStephanie FinzelFlorian KollertPublished in: Arthritis research & therapy (2019)
Inflammatory SSc is characterized by a more severe phenotype, high morbidity, and a large proportion of male patients. Even treatment with CYC does not alter CRP levels in this subpopulation with a high unmet medical need.
Keyphrases
- systemic sclerosis
- oxidative stress
- end stage renal disease
- interstitial lung disease
- ejection fraction
- newly diagnosed
- healthcare
- chronic kidney disease
- prognostic factors
- clinical trial
- peritoneal dialysis
- randomized controlled trial
- early onset
- high dose
- rheumatoid arthritis
- open label
- idiopathic pulmonary fibrosis
- smoking cessation