Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis.
Thais P BanzatoJuliana R GubianiDarlon I BernardiCláudio R NogueiraAfif F MonteiroFernanda F JulianoSeverino Matias de AlencarRonaldo Aloise PilliCarolina A de LimaGiovanna B LongatoAntonio G FerreiraMary Ann FoglioJoão E de CarvalhoDébora B Vendramini-CostaRoberto G S BerlinckPublished in: Journal of natural products (2020)
Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (1-4), with a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane skeleton; propolonones A-C (5-7), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]chromane skeleton; and propolol A (8), with a 6-(3-benzylbenzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.