Comparison of prognostic models to predict the occurrence of colorectal cancer in asymptomatic individuals: a systematic literature review and external validation in the EPIC and UK Biobank prospective cohort studies.
Todd SmithDavid C MullerKarel G M MoonsAmanda J CrossMattias JohanssonPietro FerrariGuy FagherazziPetra H M PeetersGianluca SeveriAnika HüsingRudolf KaaksAnne TjonnelandAnja OlsenKim OvervadCatalina BonetMiguel Rodriguez-BarrancoJose Maria HuertaAurelio Barricarte GurreaKathryn E BradburyAntonia TrichopoulouChristina BamiaPhilippos OrfanosDomenico PalliValeria PalaPaolo VineisBas Bueno-de-MesquitaBodil OhlssonSophia HarlidBethany Van GuelpenGuri SkeieElisabete WeiderpassMazda JenabNeil MurphyElio RiboliMarc J GunterKrasimira Jekova AleksandrovaIoanna TzoulakiPublished in: Gut (2018)
Several of these non-invasive models exhibited good calibration and discrimination within both external validation populations and are therefore potentially suitable candidates for the facilitation of risk stratification in population-based colorectal screening programmes. Future work should both evaluate this potential, through modelling and impact studies, and ascertain if further enhancement in their performance can be obtained.