Significance of sphingosine kinase 1 expression in feline mammary tumors.

Yi-Chih ChangHsiao-Li ChuangJi-Hang YinJiunn-Wang LiaoTer-Hsin ChenYu-Chih Wang

Published in: BMC veterinary research (2019)

SPHK1 over-expression in breast cancer tissues is associated with a poor prognosis in humans. SPHK1 over-expression in more aggressive FMTs provides support for a potential role of SPHK1 inhibitors for the treatment of FMTs. Targeting SPHK1 has potent cytotoxic effects in primary FMT cells. These findings suggest that further examination of the role SPHK1 plays in FMTs will pave the way for the investigation of SPHK1 inhibitors in future clinical applications.

Keyphrases

poor prognosis
long non coding rna
induced apoptosis
gene expression
binding protein
oxidative stress
current status
cell proliferation