Novel Liver Injury Phenotypes and Outcomes in Pulmonary Arterial Hypertension.
Jacqueline V ScottJude MoutchiaRobin L McClellandNadine Al-NaamaniEthan WeinbergHarold I PalevskyJasleen MinhasDina K ApplebyAkaya SmithSteven C PuglieseCorey E VentetuoloSteven M KawutPublished in: medRxiv : the preprint server for health sciences (2023)
Liver injury patterns were associated with adverse outcomes in patients with PAH and CTEPH. Randomization to active treatment of pulmonary hypertension in these clinical trials had beneficial effects on liver health compared to placebo. The independent role of liver disease (often subclinical) in determining outcomes warrants prospective studies of the clinical utility of liver phenotyping for PAH prognosis and contribution to clinical disease.
Keyphrases
- liver injury
- pulmonary arterial hypertension
- drug induced
- pulmonary hypertension
- pulmonary artery
- clinical trial
- healthcare
- mental health
- high throughput
- randomized controlled trial
- type diabetes
- phase iii
- metabolic syndrome
- coronary artery
- risk assessment
- social media
- insulin resistance
- smoking cessation
- placebo controlled
- glycemic control