Regulatory modules of human thermogenic adipocytes: functional genomics of large cohort and Meta-analysis derived marker-genes.
Beáta B TóthZoltán BartaÁkos Barnabás BartaLászló FésüsPublished in: BMC genomics (2021)
Our integrative approach-based results allowed us to investigate potential regulatory elements of thermogenesis in adipose tissue. The analyses revealed that some unique biological processes form the brown and white adipocyte phenotypes, which presumes the existence of the transitional states. The data also suggests that the two phenotypes are not mutually exclusive, and differentiation of thermogenic adipocyte requires induction of browning as well as repressions of whitening. The recognition of these simultaneous actions and the identified regulatory modules can open new direction in obesity research.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet induced
- high fat diet
- transcription factor
- endothelial cells
- single cell
- network analysis
- metabolic syndrome
- type diabetes
- weight loss
- genome wide
- electronic health record
- fatty acid
- weight gain
- climate change
- dna methylation
- machine learning
- induced pluripotent stem cells
- gene expression
- body mass index
- risk assessment
- deep learning
- data analysis