Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition.
Jian YinPeter Richard SternesMingbang WangJing SongMark MorrisonTing LiLing ZhouXin WuFusheng HeJian ZhuMatthew A BrownHuji XuPublished in: Annals of the rheumatic diseases (2019)
These findings emphasise the key role that the gut microbiome plays in driving the pathogenesis of AS and highlight potential therapeutic and/or preventative targets.