Low IGF1 and high IGFBP1 predict diabetes onset in prediabetic patients.
Nina M T MeyerStefan KabischUlrike DambeckCaroline HonsekMargrit KemperChristiana GerbrachtAyman M ArafatAndreas L BirkenfeldPeter E H SchwarzJürgen MachannMartin A OsterhoffMartin O WeickertAndreas F H PfeifferPublished in: European journal of endocrinology (2022)
Lower IGF1 and higher IGFBP1 in prediabetes predicted the incidence of T2DM, indicating an impairment of beta-cell function, which explains the unresponsiveness to lifestyle intervention.
Keyphrases
- end stage renal disease
- cardiovascular disease
- type diabetes
- randomized controlled trial
- newly diagnosed
- ejection fraction
- chronic kidney disease
- metabolic syndrome
- risk factors
- binding protein
- weight loss
- peritoneal dialysis
- cell proliferation
- adipose tissue
- patient reported outcomes
- signaling pathway
- patient reported