PTEN activates chaperone-mediated autophagy to regulate metabolism.
S Joseph EndicottRichard A MillerPublished in: Autophagy (2023)
PTEN is a negative modulator of the INS-PI3K-AKT pathway and is an essential regulator of metabolism and cell growth. PTEN is one of the most commonly mutated tumor suppressors in cancer. However, PTEN overexpression extends the lifespan of both sexes of mice. We recently showed that PTEN is necessary and sufficient to activate chaperone-mediated autophagy (CMA) in the mouse liver and cultured cells. Selective protein degradation via CMA is required to suppress glycolysis and fatty acid synthesis when PTEN is overexpressed. Thus, activation of CMA downstream of PTEN might modulate health and metabolism through selective degradation of key metabolic enzymes.
Keyphrases
- cell proliferation
- pi k akt
- signaling pathway
- cell cycle arrest
- cell death
- induced apoptosis
- endoplasmic reticulum stress
- fatty acid
- healthcare
- oxidative stress
- squamous cell carcinoma
- mental health
- type diabetes
- heat shock protein
- endothelial cells
- adipose tissue
- climate change
- young adults
- heat shock
- social media
- childhood cancer
- squamous cell