NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy.

Yoshihiro OtaniJi Young YooCole T LewisSamantha ChaoJessica SwannerToshihiko ShimizuJin Muk KangSara A Murphy Kimberly Rivera-CaraballoBangxing HongJoseph C GloriosoHiroshi NakashimaSean E Lawler Yeshavanth Kumar Banasavadi-Siddegowda John D HeissYuanqing YanGuangsheng PeiMichael A CaligiuriZhong-Ming ZhaoE Antonio ChioccaJianhua YuBalveen Kaur

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

NOTCH-induced immunosuppressive myeloid cell recruitment limited antitumor immunity. Translationally, these findings support the use of NOTCH inhibition in conjunction with oHSV therapy.

Keyphrases

high glucose
cell proliferation
diabetic rats
single cell
bone marrow
cell therapy
papillary thyroid
endothelial cells
squamous cell carcinoma
stem cells
blood brain barrier
mesenchymal stem cells
squamous cell
lymph node metastasis
replacement therapy
smoking cessation