Paclitaxel, Ifosfamide, and Cisplatin as Initial Salvage Chemotherapy for Germ Cell Tumors: Long-Term Follow-Up and Outcomes for Favorable- and Unfavorable-Risk Disease.
Jack Patrick GleesonAndrea KnezevicMaria BrombergSujata PatilJoel SheinfeldBrett S CarverManjit BainsDavid R JonesDean F BajorinGeorge J BoslDeaglan Joseph McHughSamuel A FuntRobert J MotzerDarren R FeldmanPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
TIP is an effective second-line regimen for patients with GCT. Similar outcomes were observed in patients with favorable- and unfavorable-risk disease. The randomized TIGER trial (ClinicalTrials.gov identifier: NCT02375204) comparing TIP with high-dose chemotherapy will determine the optimal second-line treatment approach.