Transcriptional and epigenetic changes after dietary and surgical weight loss interventions in an animal model of obesity.
Manel CremadesEider Talavera-UrquijoMarc BeisaniStella PappaMireia JordàJordi TarascóPau MorenoAlbert CaballeroEva Martínez-LópezSilvia PelliteroJosé María BalibreaPublished in: International journal of obesity (2005) (2023)
Changes in tissue expression of specific genes involved in the pathophysiological mechanisms of obesity can be significantly attenuated following weight loss interventions, particularly surgery. Some of these genes are regulated by epigenetic mechanisms.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- gene expression
- dna methylation
- gastric bypass
- physical activity
- minimally invasive
- poor prognosis
- weight gain
- genome wide
- glycemic control
- coronary artery bypass
- insulin resistance
- obese patients
- metabolic syndrome
- adipose tissue
- high fat diet induced
- coronary artery disease
- oxidative stress
- skeletal muscle
- binding protein
- bioinformatics analysis