Suppressive effects of plumbagin on the growth of human bladder cancer cells via PI3K/AKT/mTOR signaling pathways and EMT.
Renjie ZhangZijian WangWenjie YouFengfang ZhouZicheng GuoKaiyu QianYu XiaoXing-Huan WangPublished in: Cancer cell international (2020)
In our study. We found PL inhibits the proliferation of T24 and UMUC3 cells in vivo and in vitro, which may play a role through several downstream effectors of PI3K/AKT/mTOR signaling pathway to promote the cell cycle arrest and apoptosis. Meanwhile, we consider that PL may inhibit the migration of bladder cancer cells via EMT suppression and induce ROS generation to make cell apoptosis. This work screened out a novel chemotherapeutic drug (plumbagin) with relatively good anti-tumor activity, which possessed great potential in BCa chemotherapy.
Keyphrases
- cell cycle arrest
- pi k akt
- signaling pathway
- epithelial mesenchymal transition
- cell death
- induced apoptosis
- cell proliferation
- spinal cord injury
- endothelial cells
- emergency department
- locally advanced
- squamous cell carcinoma
- induced pluripotent stem cells
- radiation therapy
- pluripotent stem cells
- oxidative stress
- adverse drug
- human health
- climate change
- endoplasmic reticulum stress