Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection.

Tahrima KayesHarry CraneAllison SymondsJulie DumondMackenzie CottrellJulia Di GirolamoSicha ManandharTien Huey LimEdward GaneAngela KashubaMiriam Tania Levy

Published in: Alimentary pharmacology & therapeutics (2022)

In this first pharmacokinetic study of TAF monotherapy in breastfeeding women with CHB, concentrations of TAF and TFV were low in breast milk with negligible infant exposure, supporting the use of TAF to prevent MTCT.

Keyphrases

hepatitis b virus
preterm infants
combination therapy
open label
randomized controlled trial
clinical trial