Association of CYP2C19 Loss-of-Function Alleles with Major Adverse Cardiovascular Events of Clopidogrel in Stable Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention: Meta-analysis.
Mohitosh BiswasSumaiya Khatun KaliPublished in: Cardiovascular drugs and therapy (2021)
Stable CAD patients treated with clopidogrel and carried CYP2C19 LoF alleles undergoing PCI were associated with significantly increased risk of MACE compared to non-carriers, even markedly significant for Asian patients.
Keyphrases
- coronary artery disease
- percutaneous coronary intervention
- cardiovascular events
- st segment elevation myocardial infarction
- antiplatelet therapy
- st elevation myocardial infarction
- acute myocardial infarction
- coronary artery bypass grafting
- acute coronary syndrome
- systematic review
- patients undergoing
- end stage renal disease
- ejection fraction
- coronary artery bypass
- newly diagnosed
- chronic kidney disease
- prognostic factors
- type diabetes
- peritoneal dialysis
- aortic stenosis
- meta analyses
- atrial fibrillation
- randomized controlled trial
- electronic health record