Antileishmanial effects of γCdcPLI, a phospholipase A2 inhibitor from Crotalus durissus collilineatus snake serum, on Leishmania (Leishmania) amazonensis.

Marina Neves GonçalvesDaiana Silva LopesSamuel Cota TeixeiraThaise Lara TeixeiraVitor de FreitasTássia Rafaella CostaSarah Natalie Cirilo GimenesIsabella Mitie de CamargoGuilherme de SouzaMarcelo Santos da SilvaFernanda Van Petten de Vasconcelos AzevedoKathleen Fernandes GregoLuísa Carregosa SantosVinícius Queiroz OliveiraClaudio Vieira da SilvaRenata Santos RodriguesKelly Aparecida Geraldo YoneyamaPatricia Bianca ClissaVeridiana de Melo Rodrigues

Published in: Memorias do Instituto Oswaldo Cruz (2023)

γCdcPLI is an interesting tool for the discovery of new essential targets on the parasite, as well as an alternative compound to improve the effectiveness of the leishmaniasis treatment.

Keyphrases

randomized controlled trial
systematic review
small molecule
high throughput
combination therapy
toxoplasma gondii
trypanosoma cruzi
smoking cessation