Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues.

Satoshi MuraokaAnnina M DeLeoManveen K SethiKayo Yukawa-TakamatsuZijian YangJina KoJohn D HoganZhi RuanYang YouYuzhi WangMaria MedallaSeiko IkezuMei ChenWeiming XiaSanthi GorantlaHoward E GendelmanDavid IssadoreJoseph ZaiaTsuneya Ikezu

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2020)

In addition to Aβ and tau, ANXA5, VGF, GPM6A, and ACTZ are new signature proteins in AD EVs.

Keyphrases

gene expression
cognitive decline
single cell
cerebrospinal fluid
label free
mild cognitive impairment