Tsuneya Ikezu

Loop profile Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 33

Top Venues

Journal of extracellular vesicles

Journal of extracellular biology

Science advances

Molecular neurodegeneration

Boston University School of Medicine

University of Tokyo Graduate School of Medicine (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Boston University School of Medicine Apr 01 2010

United States

Professor :: Pharmacology and Neurology

University of Nebraska Medical Center Oct 01 1999 - Mar 31 2010

United States

Assistant-Full Professor :: Pharmacology and Experimental Neuroscience

Education History

University of Tokyo Graduate School of Medicine - Mar 23 1997

Japan

PHD

Publications

Ursula S Sandau, Setty M Magaña, Julia Costa, John P Nolan, Tsuneya Ikezu, Laura J Vella, Hannah K Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F Hill, Joseph F Quinn, Kendall R Van Keuren-Jensen, Trevor J McFarland, Joanna Palade, Eric A Sribnick, Huaqi Su, Kostas Vekrelli S, Beth Coyle, Yang You, Juan Manuel Falcon-Perez, Rienk Nieuwland, Julie A Saugstad, null null
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. Journal of extracellular vesicles 13 (1) (2024)
Ursula S Sandau, Setty M Magaña, Julia Costa, John P Nolan, Tsuneya Ikezu, Laura J Vella, Hannah K Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F Hill, Joseph F Quinn, Kendall R Van Keuren-Jensen, Trevor J McFarland, Joanna Palade, Eric A Sribnick, Huaqi Su, Kostas Vekrelli S, Beth Coyle, Yang You, Juan Manuel Falcon-Perez, Rienk Nieuwland, Julie A Saugstad, null null
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. Journal of extracellular vesicles 13 (1) (2024)
Mohammad Abdullah, Zhi Ruan, Seiko Ikezu, Tsuneya Ikezu
P2RX7 plays a critical role in extracellular vesicle-mediated secretion of pathogenic molecules from microglia and astrocytes. Journal of extracellular biology 3 (7) (2024)
Carlos J Nogueras-Ortiz, Erden Eren, Pamela Yao, Elizabeth Calzada, Christopher Dunn, Olga Volpert, Francheska Delgado-Peraza, Maja Mustapic, Alexey Lyashkov, F Javier Rubio, Michael Vreones, Lesley Cheng, Yang You, Andrew F Hill, Tsuneya Ikezu, Erez Eitan, Edward J Goetzl, Dimitrios Kapogiannis
Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs. Journal of extracellular vesicles 13 (6) (2024)
Mohammad Abdullah, Zhi Ruan, Seiko Ikezu, Tsuneya Ikezu
P2RX7 plays a critical role in extracellular vesicle-mediated secretion of pathogenic molecules from microglia and astrocytes. Journal of extracellular biology 3 (7) (2024)
Carlos J Nogueras-Ortiz, Erden Eren, Pamela Yao, Elizabeth Calzada, Christopher Dunn, Olga Volpert, Francheska Delgado-Peraza, Maja Mustapic, Alexey Lyashkov, F Javier Rubio, Michael Vreones, Lesley Cheng, Yang You, Andrew F Hill, Tsuneya Ikezu, Erez Eitan, Edward J Goetzl, Dimitrios Kapogiannis
Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs. Journal of extracellular vesicles 13 (6) (2024)
Ursula S Sandau, Setty M Magaña, Julia Costa, John P Nolan, Tsuneya Ikezu, Laura J Vella, Hannah K Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F Hill, Joseph F Quinn, Kendall R Van Keuren-Jensen, Trevor J McFarland, Joanna Palade, Eric A Sribnick, Huaqi Su, Kostas Vekrelli S, Beth Coyle, Yang You, Juan Manuel Falcon-Perez, Rienk Nieuwland, Julie A Saugstad, null null
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. Journal of extracellular vesicles 13 (1) (2024)
Carlos J Nogueras-Ortiz, Erden Eren, Pamela Yao, Elizabeth Calzada, Christopher Dunn, Olga Volpert, Francheska Delgado-Peraza, Maja Mustapic, Alexey Lyashkov, F Javier Rubio, Michael Vreones, Lesley Cheng, Yang You, Andrew F Hill, Tsuneya Ikezu, Erez Eitan, Edward J Goetzl, Dimitrios Kapogiannis
Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs. Journal of extracellular vesicles 13 (6) (2024)
Mohammad Abdullah, Zhi Ruan, Seiko Ikezu, Tsuneya Ikezu
P2RX7 plays a critical role in extracellular vesicle-mediated secretion of pathogenic molecules from microglia and astrocytes. Journal of extracellular biology 3 (7) (2024)
Ursula S Sandau, Setty M Magaña, Julia Costa, John P Nolan, Tsuneya Ikezu, Laura J Vella, Hannah K Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F Hill, Joseph F Quinn, Kendall R Van Keuren-Jensen, Trevor J McFarland, Joanna Palade, Eric A Sribnick, Huaqi Su, Kostas Vekrelli S, Beth Coyle, Yang You, Juan Manuel Falcon-Perez, Rienk Nieuwland, Julie A Saugstad, null null
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. Journal of extracellular vesicles 13 (1) (2024)
Mohammad Abdullah, Zhi Ruan, Seiko Ikezu, Tsuneya Ikezu
P2RX7 plays a critical role in extracellular vesicle-mediated secretion of pathogenic molecules from microglia and astrocytes. Journal of extracellular biology 3 (7) (2024)
Ursula S Sandau, Setty M Magaña, Julia Costa, John P Nolan, Tsuneya Ikezu, Laura J Vella, Hannah K Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F Hill, Joseph F Quinn, Kendall R Van Keuren-Jensen, Trevor J McFarland, Joanna Palade, Eric A Sribnick, Huaqi Su, Kostas Vekrelli S, Beth Coyle, Yang You, Juan Manuel Falcon-Perez, Rienk Nieuwland, Julie A Saugstad, null null
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. Journal of extracellular vesicles 13 (1) (2024)
Yunjung Jin, Fuyao Li, Zonghua Li, Tadafumi C Ikezu, Justin O'Leary, Manikandan Selvaraj, Yiyang Zhu, Yuka A Martens, Shunsuke Koga, Hannah Santhakumar, Yonghe Li, Wenyan Lu, Yang You, Kiara Lolo, Michael A DeTure, Alexandra I Beasley, Mary D Davis, Pamela J McLean, Owen A Ross, Takahisa Kanekiyo, Tsuneya Ikezu, Thomas R Caulfield, Jonathan A Carr, Zbigniew K Wszolek, Guojun Bu, Gourisankar Ghosh, Na Zhao
Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs. Science advances 10 (37) (2024)
Carlos J Nogueras-Ortiz, Erden Eren, Pamela Yao, Elizabeth Calzada, Christopher Dunn, Olga Volpert, Francheska Delgado-Peraza, Maja Mustapic, Alexey Lyashkov, F Javier Rubio, Michael Vreones, Lesley Cheng, Yang You, Andrew F Hill, Tsuneya Ikezu, Erez Eitan, Edward J Goetzl, Dimitrios Kapogiannis
Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs. Journal of extracellular vesicles 13 (6) (2024)
Zhuoran Yin, Shawn Herron, Sebastian Silveira, Kilian Kleemann, Christian Gauthier, Dania Mallah, Yiran Cheng, Milica A Margeta, Kristen M Pitts, Jen-Li Barry, Ayshwarya Subramanian, Hannah Shorey, Wesley Brandao, Ana Durao, Jean-Christophe Delpech, Charlotte Madore, Mark Jedrychowski, Amrendra Kumar Ajay, Gopal Murugaiyan, Samuel W Hersh, Seiko Ikezu, Tsuneya Ikezu, Oleg Butovsky
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease. Nature neuroscience (2023)
Yang You, Zhengrong Zhang, Nadia Sultana, Maria Ericsson, Yuka A Martens, Min Kyoung Sun, Takahisa Kanekiyo, Seiko Ikezu, Scott A Shaffer, Tsuneya Ikezu
ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. Science advances 9 (37) (2023)
Zhuoran Yin, Neta Rosenzweig, Kilian L Kleemann, Xiaoming Zhang, Wesley Brandão, Milica A Margeta, Caitlin Schroeder, Kisha N Sivanathan, Sebastian Silveira, Christian Gauthier, Dania Mallah, Kristen M Pitts, Ana Durao, Shawn Herron, Hannah Shorey, Yiran Cheng, Jen-Li Barry, Rajesh K Krishnan, Sam Wakelin, Jared Rhee, Anthony Yung, Michael Aronchik, Chao Wang, Nimansha Jain, Xin Bao, Emma Gerrits, Nieske Brouwer, Amy Anderson Deik, Daniel Geoffrey Tenen, Tsuneya Ikezu, Nicolás Santander Grez, Gabriel L McKinsey, Caroline Baufeld, Dean Sheppard, Susanne Krasemann, Roni Nowarski, Bart J L Eggen, Andrew T Chan, Rudolph E Tanzi, Charlotte Madore, Thomas D Arnold, David M Holtzman, Oleg Butovsky
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nature immunology (2023)
Zhengrong Zhang, Kaiwen Yu, Yang You, Peizhou Jiang, Zhiping Wu, Michael A DeTure, Dennis W Dickson, Seiko Ikezu, Junmin Peng, Tsuneya Ikezu
Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. Journal of extracellular vesicles 12 (8) (2023)
Yang You, Samuel W Hersh, Roshanak Aslebagh, Scott A Shaffer, Seiko Ikezu, Jesse Mez, Kathryn L Lunetta, Mark W Logue, Lindsay A Farrer, Tsuneya Ikezu
Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging cell 21 (6) (2022)
Yang You, Satoshi Muraoka, Mark P Jedrychowski, Jianqiao Hu, Amanda K McQuade, Tracy Young-Pearse, Roshanak Aslebagh, Scott A Shaffer, Steven P Gygi, Mathew Blurton-Jones, Wayne W Poon, Tsuneya Ikezu
Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. Journal of extracellular vesicles 11 (1) (2022)
Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Charles Mosier, Janneca Ames, Charisse Winston, Christopher B Lietz, Zhenze Jiang, Anthony J O'Donoghue, Tsuneya Ikezu, Robert A Rissman, Shauna H Yuan, Vivian Hook
Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS omega 6 (20) (2021)
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C Hays, Patrick R Hof, William Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I Luebke, Tsuneya Ikezu
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Science translational medicine 13 (611) (2021)
Satoshi Muraoka, Mark P Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D Onos, Kelly J Keezer, Jianqiao Hu, Seiko Ikezu, Gareth R Howell, Steven P Gygi, Tsuneya Ikezu
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. Journal of proteome research 20 (3) (2021)
Rebecca Panitch, Junming Hu, Jaeyoon Chung, Congcong Zhu, Gaoyuan Meng, Weiming Xia, David A Bennett, Kathryn L Lunetta, Tsuneya Ikezu, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Jun
Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. Molecular psychiatry (2021)
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikezu
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration 16 (1) (2021)
Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Molecular neurodegeneration 15 (1) (2020)
Satoshi Muraoka, Annina M DeLeo, Manveen K Sethi, Kayo Yukawa-Takamatsu, Zijian Yang, Jina Ko, John D Hogan, Zhi Ruan, Yang You, Yuzhi Wang, Maria Medalla, Seiko Ikezu, Mei Chen, Weiming Xia, Santhi Gorantla, Howard E Gendelman, David Issadore, Joseph Zaia, Tsuneya Ikezu
Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimer's & dementia : the journal of the Alzheimer's Association 16 (6) (2020)
Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, Maya E Woodbury, Alicia A Van Enoo, Zhi Ruan, Sudhir Sivakumaran, Yang You, Carl Holland, Teresa Guillamon-Vivancos, Asuka Yoshii-Kitahara, Mina B Botros, Charlotte Madore, Pin-Hao Chao, Ankita Desani, Solaiappan Manimaran, Srinidhi Venkatesan Kalavai, W Evan Johnson, Oleg Butovsky, Maria Medalla, Jennifer I Luebke, Tsuneya Ikezu
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Molecular psychiatry 26 (6) (2020)
Tsuneya Ikezu, Lacin Koro, Benjamin Wolozin, Francis A Farraye, Audrey J Strongosky, Zbigniew K Wszolek
Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 15 (4) (2020)
Seiko Ikezu, Kaitlin L Ingraham Dixie, Lacin Koro, Takashi Watanabe, Kozo Kaibuchi, Tsuneya Ikezu
Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta neuropathologica communications 8 (1) (2020)
Yang You, Kathleen Borgmann, Venkata Viswanadh Edara, Satomi Stacy, Anuja Ghorpade, Tsuneya Ikezu
Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing. Journal of extracellular vesicles 9 (1) (2019)
Daniel J Apicco, Peter E A Ash, Brandon Maziuk, Chelsey LeBlang, Maria Medalla, Ali Al Abdullatif, Antonio Ferragud, Emily Botelho, Heather I Ballance, Uma Dhawan, Samantha Boudeau, Anna Lourdes Cruz, Daniel Kashy, Aria Wong, Lisa R Goldberg, Neema Yazdani, Cheng Zhang, Choong Y Ung, Yorghos Tripodis, Nicholas M Kanaan, Tsuneya Ikezu, Pietro Cottone, John Leszyk, Hu Li, Jennifer Luebke, Camron D Bryant, Benjamin Wolozin
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nature neuroscience 21 (1) (2017)
Annina M DeLeo, Tsuneya Ikezu
Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 13 (3) (2017)
Maya E Woodbury, Robert W Freilich, Christopher J Cheng, Hirohide Asai, Seiko Ikezu, Jonathan D Boucher, Frank Slack, Tsuneya Ikezu
miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience 35 (26) (2015)

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Publication Activity (10 Years)

Top Topics

Top Venues

Tsuneya Ikezu