Peripheral blood mononuclear cell transcriptome profile in a clinical trial with subcutaneous, grass pollen allergoid immunotherapy.
Sviatlana StarchenkaKemi OluwayiMatthew D HeathOliver ArmfieldM H Mohamed ShamjiJanice A LayhadiKatarzyna LisLisa CadavezOlesya RusynMurray SkinnerPieter-Jan De KamPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)
Peripheral blood mononuclear cells transcriptome profile showed an inhibition of Th2, Th17 pro-inflammatory allergic responses and immune deviation towards Th1 responses. PQ Grass extended regimen exhibited a superior mechanistic efficacy profile in comparison with PQ conventional regimen.