[Clinical importance of evaluation of circulating miRNA expression and epicardial adipose tissue thickness as predictors of cardiovascular pathology in young patients with type 1 diabetes mellitus].
O I VengrzhinovskayaI Z BondarenkoO A ShatskayaN V TarbaevaA Y KornelukV Y KalashnikovM V ShestakovaNatalia G MokryshevaPublished in: Terapevticheskii arkhiv (2023)
Structural and functional changes in the cardiovascular system (including thickening of the EAT), shifts in miR-126-5p expression and adipokines profile are observed already at a young age in patients with T1DM. In T1DM, diffuse vascular fibrosis is detected in 16% of patients. The data obtained were used to identify the group increased risk of developing CVD in T1DM and served as the basis for determining the timing of the start of preventive therapy.
Keyphrases
- adipose tissue
- poor prognosis
- end stage renal disease
- glycemic control
- ejection fraction
- chronic kidney disease
- newly diagnosed
- middle aged
- insulin resistance
- peritoneal dialysis
- binding protein
- type diabetes
- prognostic factors
- stem cells
- electronic health record
- mesenchymal stem cells
- low grade
- metabolic syndrome
- deep learning
- high grade