Telomerase reverse transcriptase immunohistochemical expression is sensitive but not specific for TERT gene amplification in acral melanoma.
Woo Cheal ChoWen LiJun GuWei-Lien WangJing NingSteven SfamenosPavandeep GillPriyardhisini NagarajanJonathan L CurryAlexander J LazarVictor G PrietoCarlos A Torres-CabalaLeomar Y BallesterPublished in: Journal of cutaneous pathology (2023)
The clinical utility of TERT IHC to predict TGA status in AMs appears to be limited given its low specificity and positive predictive value.