LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients.
Emily C HardinSimone SchmidAlexander SommerkampCarina BoddenAnna-Elisa HeipertzPhilipp SieversAndrea WittmannTill MildeStefan M PfisterAndreas von DeimlingSvea HornNina A HerzMichèle SimonAshwyn A PereraAmedeo AziziOfelia CruzSarah CurryAn Van DammeMiklos GaramiDarren HargraveAntonis KattamisBarbara Faganel KotnikPäivi Maria LähteenmäkiKatrin ScheinemannAntoinette Y N Schouten-van MeeterenAstrid SehestedElisabetta ViscardiOle Mikal WormdalMichal ZapotockyDavid S ZieglerArend KochPablo Hernáiz DrieverOlaf WittDavid CapperFelix SahmDavid T W JonesCornelis M van TilburgPublished in: Neuro-oncology (2023)
The addition of RNA-Seq to current diagnostic methods improves diagnostic accuracy, making precision oncology treatments (MEKi/RAFi/ERKi/NTRKi/FGFRi/ROSi) more accessible. We propose to include RNA-Seq as part of routine diagnostics for all pLGG patients, especially when no common pLGG alteration was identified.