Twelve-week treadmill endurance training in mice is associated with upregulation of interleukin-15 and natural killer cell activation and increases apoptosis rate in Hepa1-6 cell-derived mouse hepatomas.
Zhe WangYunlong CuiYong ZhangXinghao WangJing LiJialin LiNing JiangPublished in: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (2023)
Regular exercise reduces the risk of malignancy and decreases the recurrence of cancer. However, the mechanisms behind this protection remain to be elucidated. Natural killer (NK) cells are lymphocytes of the innate immune system, which play essential roles in immune defense and effectively prevent cancer metastasis. Physical exercise can increase the activity of NK cells. Interleukin-15 (IL-15) is the best-studied cytokine activator of NK cells, and it was shown to have many positive functional effects on NK cells to improve antitumor responses. The aim of this study was to clarify the possible important mechanisms behind endurance exercise-induced changes in NK cell function, which may be highly correlated with IL-15. An animal model was used to study IL-15 expression level, tumor volume, cancer cell apoptosis, and NK cell infiltration after treadmill exercise. Although IL-15 was highly expressed in skeletal muscle, treadmill exercise further elevated IL-15 levels in plasma and muscle (P<0.05). In addition, tumor weight and volume of tumor-bearing mice were decreased (P<0.05), and liver tumor cell apoptosis was increased after 12 weeks of treadmill exercise (P<0.05). NK cell infiltration was upregulated in tumors from treadmill exercise mice, and the level of interferon-gamma (IFN-γ) and IL-15 were higher than in sedentary mice (P<0.05). The study indicated that regular endurance training can reduce cancer risk, which was related to increased IL-15 expression, activation of the immune killing effect of NK cells, and promotion of tumor cell apoptosis, which can ultimately control tumor growth.
Keyphrases
- nk cells
- high intensity
- skeletal muscle
- resistance training
- physical activity
- papillary thyroid
- poor prognosis
- cell proliferation
- high fat diet induced
- immune response
- dendritic cells
- squamous cell carcinoma
- oxidative stress
- body composition
- stem cells
- insulin resistance
- clinical trial
- body mass index
- lymph node metastasis
- young adults
- cell therapy
- endoplasmic reticulum stress
- wild type
- childhood cancer
- solid state