SARS-CoV-2-Related Olfactory Dysfunction: Autopsy Findings, Histopathology, and Evaluation of Viral RNA and ACE2 Expression in Olfactory Bulbs.

Marco Dell' Aquila Concetta Cafiero Alessandra MiceraEgidio StiglianoMaria Pia OttaianoGiulio Benincasa Beniamino Schiavone Leo Guidobaldi Luigi SantacroceSalvatore PiscontiVincenzo ArenaRaffaele Palmirotta

Published in: Biomedicines (2024)

Our finding suggests that COVID-19 anosmia is not only due to neurotropism and the direct action of SARS-CoV-2 entering the olfactory bulb. The mechanism of SARS-CoV-2 neuropathogenesis in the olfactory bulb requires a better elucidation and further research studies to mitigate the olfactory bulb damage associated with virus action.

Keyphrases

sars cov
respiratory syndrome coronavirus
poor prognosis
coronavirus disease
long non coding rna
drug induced
case control