Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
Mahmoud AbdellatifViktoria Trummer-HerbstAlexander Martin HeberleAlina HumnigTobias PendlSylvère DurandGiulia CerratoSebastian J HoferMoydul IslamJulia VoglhuberJose M Ramos PittolOliver KeppGerald HoeflerAlbrecht SchmidtPeter P RainerDaniel ScherrDirk von LewinskiEgbert BispingJulie R McMullenAbhinav DiwanTobias EisenbergFrank MadeoKathrin ThedieckGuido KroemerSimon SedejPublished in: Circulation (2022)
Our findings indicate that the relationship between IGF1R signaling and cardiac health is not linear, but rather biphasic. Hence, pharmacological inhibitors of the IGF1 pathway, albeit unsuitable for young individuals, might be worth considering in older adults.