First-in-Human Assessment of cRGD-ZW800-1, a Zwitterionic, Integrin-Targeted, Near-Infrared Fluorescent Peptide in Colon Carcinoma.
Kim S de ValkMarion M DekenHenricus J M HandgraafShadhvi S BhairosinghOkker D BijlstraMichiel Joost van EsdonkAnton G T Terwisscha van ScheltingaA Rob P M ValentijnTaryn L MarchJaap VuijkKoen C M J PeetersFabian A HolmanDenise E HillingJ Sven D MieogJohn V FrangioniJacobus BurggraafAlexander L VahrmeijerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
cRGD-ZW800-1 enabled fluorescence imaging of colon cancer in both open and minimal invasive surgeries. Further development of cRGD-ZW800-1 for widespread use in cancer surgery may be warranted given the ubiquitous overexpression of various integrins on different types of tumors and their vasculature.
Keyphrases
- fluorescence imaging
- minimally invasive
- photodynamic therapy
- endothelial cells
- papillary thyroid
- coronary artery bypass
- cell proliferation
- squamous cell
- quantum dots
- induced pluripotent stem cells
- cancer therapy
- pluripotent stem cells
- transcription factor
- living cells
- lymph node metastasis
- atrial fibrillation
- childhood cancer
- acute coronary syndrome
- coronary artery disease
- percutaneous coronary intervention