Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells.

Shigeo HisamoriJunko MukohyamaSanjay KoulTakanori HayashiMichael Evan RothenbergMasao MaedaTaichi IsobeLuis Enrique Valencia SalazarXin QianDarius Michael JohnstonDalong QianKaiqin LaoNaoya AsaiYoshihiro KakejiVincenzo Alessandro GennarinoDebashis SahooPiero DalerbaYohei Shimono

Published in: Journal of gastroenterology (2022)

In the colon epithelium, terminal differentiation associates with the coordinated upregulation of miR-200c and miR-203, which cooperate to suppress BMI1 and disable the expansion capacity of epithelial cells.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
poor prognosis
body mass index
signaling pathway
weight gain
physical activity
weight loss