Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.
Maulasri BhattaGautam N ShenoyJenni L LoyallBrian D GrayMeghana BapardekarAlexis ConwayHans MindermanRaymond J KelleherBeatriz M CarrenoGerald P LinetteLeonard D ShultzKunle OdunsiSathy V Balu-IyerKoon Yan PakRichard B BankertPublished in: Journal for immunotherapy of cancer (2022)
Our results establish that targeting exosomal PS in TMEs with ExoBlock represents a promising strategy to enhance antitumor T-cell responses.